Continuing into this era:
- Evolution: The Story of Life on Earth
- Covers the evolution of life on Earth from its beginnings to the present day.
- Amazons, Abolitionists, and Activists: A Graphic History of Women’s Fight for Their Rights
- (4500 BCE — 2019 CE)
- Not the Israel My Parents Promised Me
- Details the history of the Israelites, Jews and Israelis from the time of Abraham onwards.
- Action Philosophers!
- details the lives and ideas of philosophers throughout human history
- The Cartoon History of the Universe III: From the Rise of Arabia to the Renaissance
- Details events from 395 CE, with some additional material covering the earlier history of Africa, and ends with the voyage of Columbus in 1492 CE.
Beginning in this era:
- Lords of the Sea: The Vikings Explore the North Atlantic
- Ninth, Tenth and Eleventh Centuries CE
- The Bayeux Tapestry
- Details the Battle of Hastings in 1066. (This is pushing it a little, I know, but if it’s good enough for Scott McCloud and Bryan Talbot, it’s good enough for me.)
- Prithviraj Chauhan
- Details the marriage and later life of Prithviraj Chauhan from 1175 to his death in 1192.
- Nevsky
- (1227 – 1242)
- The Adventures of Marco Polo
- (September 15, 1254 – January 9, 1324)
- Crecy
- Details the battle at Crecy in 1346.
- Chiaroscuro: The Private Lives of Leonardo da Vinci
- He is the Renaissance Man, after all. This title also appears in the Vertigo Universe timeline.
- Messenger: The Legend of Joan of Arc
- Details the final years of Joan of Arc, from 1424 – 1431.
- Christopher Columbus: Famous Explorer
- (1451 – 1506)
- Vlad the Impaler
- (1447 – 1476)
- Soordas
- (1478 – 1581)
- Borgia: Blood for the Pope
- Borgia: Power and Incest
- These two volumes detail the fortunes of the Borgia family from 1492 onwards
- The Cartoon History of the Modern World Part 1: From Columbus to the U.S. Constitution
- Covers the history of the Americas, up to and including Columbus, and carrying on to the American Revolution.
- The 500 Years of Resistance Comic Book: Revised and Expanded
- (1492 – 2016)
- Pizarro and the Incas
- (1524 – 1541)
- The Mystery of the Roanoke Colony
- (1587 – 1590)
- Elizabeth I and The Spanish Armada
- (1588)